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By Michael Robertson

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Echocardiogram 8. Troponin and MB fraction Creatine Kinase 9. EEG (where indicated) Table 1. – Procedure for initiation of clozapine treatmen Baldessarini RJ, Frankenburg FR. A novel antipsychotic agent. New England Journal Medicine. 1991;324(11):746-54 and UK clozapine study group. The safety and efficacy of clozapine in severe treatment-resistant schizophrenic patients in the UK. British Journal Psych. 1993;150-54. 40. Kane J, Honigfield G, Singer J, et al. Clozapine for the treatment-resistant schizophrenic; results of a US multicenter trial.

1-3) The 3 Figures show a typical EEG trace recorded during ECT treatment. A stimulus is delivered and different neuronal clusters discharge paroxysmally, resulting in an EEG trace which is erratic and irregular. This is described as the ‘recruitment phase’ (Fig. 1). As these discharges summate and become synchronous, the EEG assumes a more uniform appearance, as the seizure occurs and seizure complexes appear (Fig. 2). The seizure leads to the discharge of inhibitory interneurones, which results in a flattened EEG appearance in a phase described as ‘post-ictal suppression’ (Fig.

Echocardiogram 8. Troponin and MB fraction Creatine Kinase 9. EEG (where indicated) Table 1. – Procedure for initiation of clozapine treatmen Baldessarini RJ, Frankenburg FR. A novel antipsychotic agent. New England Journal Medicine. 1991;324(11):746-54 and UK clozapine study group. The safety and efficacy of clozapine in severe treatment-resistant schizophrenic patients in the UK. British Journal Psych. 1993;150-54. 40. Kane J, Honigfield G, Singer J, et al. Clozapine for the treatment-resistant schizophrenic; results of a US multicenter trial.

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